2-Zoloft: Incr MORPHINE-pk
Zoloft(SERTRALINE) will increase the level or effect of MORPHINE by hepatic enzyme CYP2D6 metabolism.
Significant interaction possible, monitor closely.

3- Incr Atc:ASPIRIN,RETEPLASE-pd
ASPIRIN and RETEPLASE both increase anticoagulation. Potential for dangerous interaction; Use with caution and monitor closely.

2-Zoloft: Incr Toprol XL-pk
Zoloft(SERTRALINE) will increase the level or effect of Toprol XL(METOPROLOL) by hepatic enzyme CYP2D6 metabolism.
Significant interaction possible, monitor closely.

2-Zoloft:ASPIRIN-other
Zoloft(SERTRALINE), ASPIRIN.
Either increases toxicity of the other by pharmacodynamic synergism.
Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
Significant interaction possible, monitor closely.

3- Incr St:Zoloft,MORPHINE-pd
Zoloft(SERTRALINE) and MORPHINE both increase serotonin levels. Potential for dangerous interaction; Use with caution and monitor closely.

2-ASPIRIN:Toprol XL-other
ASPIRIN decreases effects of Toprol XL(METOPROLOL) by pharmacodynamic antagonism.
Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
Significant interaction possible, monitor closely.

2- Incr Pt:Toprol XL,ASPIRIN-pd
Toprol XL(METOPROLOL) and ASPIRIN both increase serum potassium. Potential for interaction; monitor.